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Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

1
Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran
2
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran
3
Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(2), 181; https://doi.org/10.3390/jcm10020181
Received: 28 November 2020 / Revised: 25 December 2020 / Accepted: 28 December 2020 / Published: 6 January 2021
(This article belongs to the Section Pharmacology)
Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.
Keywords: microneedle arrays; drug delivery; immunotherapy; vaccination; gene delivery; nanomedicine microneedle arrays; drug delivery; immunotherapy; vaccination; gene delivery; nanomedicine
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MDPI and ACS Style

Alimardani, V.; Abolmaali, S.S.; Yousefi, G.; Rahiminezhad, Z.; Abedi, M.; Tamaddon, A.; Ahadian, S. Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics. J. Clin. Med. 2021, 10, 181.

AMA Style

Alimardani V, Abolmaali SS, Yousefi G, Rahiminezhad Z, Abedi M, Tamaddon A, Ahadian S. Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics. Journal of Clinical Medicine. 2021; 10(2):181.

Chicago/Turabian Style

Alimardani, Vahid; Abolmaali, Samira Sadat; Yousefi, Gholamhossein; Rahiminezhad, Zahra; Abedi, Mehdi; Tamaddon, Alimohammad; Ahadian, Samad. 2021. "Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics" J. Clin. Med. 10, no. 2: 181.

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